San Francisco 49ers star defensive end Nick Bosa is set to miss the remainder of the 2025 season after tearing his ACL in a game against the Arizona Cardinals.
Bosa, who has a history of ACL injuries, will require season-ending surgery and is expected to return in 2026. The injury occurred during the first quarter of the 49ers 16-15 victory over the Arizona Cardinals, with Bosa walking to the locker room and not returning. His injury will impact the team’s defense significantly, as they will have to rely on depth players like rookie Mykel Williams and Bryce Huff. This adds to a growing list of injuries for the 49ers, as stars on the offensive side, including tight end George Kittle and quarterback Brock Purdy, are also out with injuries.