World’s Oldest Woman, María Branyas, Reveals Secret to 117 Years of Longevity
María Branyas, confirmed as the world’s oldest living person at 117 years old, has become a focal point for researchers investigating the genetic, environmental, and lifestyle factors that contributed to her extraordinary lifespan. Born in San Francisco and later moving to Spain, Branyas passed away on August 19, 2024, leaving behind a legacy of health and vitality. Scientists from the Josep Carreras Institute in Barcelona, Spain, led by Dr. Manel Esteller, conducted a comprehensive study of her biological markers, including her genome, epigenome, transcriptome, proteome, and metabolic profile, to uncover the secrets of her longevity.
Branyas’ genetic makeup was found to include variants associated with enhanced lifespan in other species, such as dogs, worms, and flies. Additionally, her genome contained protective traits against age-related diseases like cancer, Alzheimer’s, and metabolic disorders. A critical finding was her gut microbiome’s composition, which featured a significant presence of Bifidobacterium, a beneficial bacteria known for its role in immune support, metabolic regulation, and digestion. This was attributed to her frequent consumption of yogurt.
In addition to her microbiome, Branyas’ lifestyle played a vital role in her long life. She maintained a frugal diet, avoided alcohol and tobacco, and cultivated a strong sense of emotional well-being and social connection. Researchers noted that her biological age was younger than her chronological age, as indicated by epigenetic markers suggesting a slower aging process. However, the study also acknowledged the complexities of aging, emphasizing that individual factors, including genetics and environmental influences, significantly shape the aging process.
While the researchers identified multiple contributing factors, they also highlighted the need for further studies to fully understand the interplay between genetics, environment, and lifestyle in aging. The study, published in the journal Cell Reports Medicine, aims to provide insights into the biological mechanisms of supercentenarians — individuals living beyond 110 years. Branyas’ case remains a unique example of how these elements may combine to support a long and fulfilling life, offering potential avenues for future research in the field of healthy aging.
Branyas’ legacy also includes her perspective on longevity, which she described as a combination of good genetics, a healthy lifestyle, and a positive outlook on life. Her contributions to science, including her participation in the study, underscore the importance of individuals like her in advancing medical knowledge. As researchers continue to explore the biological and environmental factors that influence aging, Branyas’ story serves as both an inspiration and a resource for future scientific inquiry into human longevity.