Research led by the University of Oslo has explored the potential of NAD+ supplements in promoting healthy aging and combating certain diseases. This study, published in the journal Nature Aging, suggests that restoring NAD+ levels in the body may help in slowing age-related decline and potentially treating neurodegenerative conditions such as Alzheimer’s and Parkinson’s. NAD+, a molecule essential for cellular function and survival, naturally declines with age, and various supplements have emerged to counter this decline.
The findings highlight that boosting NAD+ levels can improve mitochondrial function and stem cell activity, leading to better energy metabolism, enhanced focus, and support for tissue repair and immune defense. Dr. Amanda Kahn, a board-certified internist and longevity expert, noted that NAD+ is central to maintaining youthful cellular function and can protect against DNA damage and inflammation. She emphasized that while these findings are promising, they are still in the early stages, and more research is needed before NAD+ supplements can be recommended more broadly.
The review study also indicated that NAD+ could help in neuroprotection, reducing inflammation, and improving insulin sensitivity. Dr. Halland Chen, a longevity expert, added that preliminary studies in animals and early human models show that maintaining healthy NAD+ levels can improve various aspects of health. However, he warned that larger human clinical trials are still necessary to confirm these results. Despite these caveats, many individuals have reported positive outcomes from NAD+ therapy, including increased energy, better focus, and improved recovery.
There are multiple ways to boost NAD+ levels, including taking oral supplements such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). For those seeking more immediate results, IV infusions have shown greater effectiveness. These methods are commonly used, with sessions often involving a series of infusions followed by regular maintenance. The therapy has been particularly beneficial for individuals managing fatigue, metabolic issues, or neurodegenerative decline. However, experts caution that these treatments should not be viewed as a shortcut to longevity, and maintaining a healthy lifestyle with proper sleep, nutrition, and exercise is essential for overall well-being.
Despite their potential, researchers also highlight that NAD+ therapy is generally safe, with mild side effects such as headaches, nausea, and transient allergic reactions. These are typically short-lived and can be managed under medical supervision. Experts advise individuals, especially those with pre-existing health conditions, to consult a healthcare provider before starting any NAD+ regimen. While the research is promising, the full potential of NAD+ supplements needs to be further validated through comprehensive studies to ensure their efficacy and safety for widespread use.