Study Highlights Risk of Heart Failure from Long-Term Melatonin Use
A new study reveals that long-term use of melatonin supplements may significantly increase the risk of heart failure in patients with chronic insomnia, raising concerns about the safety of this popular sleep aid. The research, conducted by the American Heart Association, examines over five years of health records from 130,828 adults with insomnia, highlighting a 90% higher risk of heart failure among those who took melatonin for at least one year versus non-users.
Melatonin, a naturally produced hormone that regulates sleep, has become widely available as an over-the-counter supplement, particularly in the U.S. While it is often considered a safe and natural option for improving sleep, the study found that its long-term use may be associated with serious health outcomes, including heart failure, hospitalization, and increased mortality. The research emphasizes the need for further investigation and calls for caution in its use, especially for individuals with chronic insomnia.
Lead author Dr. Ekenedilichukwu Nnadi, a chief resident in internal medicine at SUNY Downstate/Kings County Primary Care in Brooklyn, New York, noted that the findings challenge the common perception of melatonin as a harmless supplement. “Melatonin supplements are widely thought of as a safe and natural option to support better sleep, so it was striking to see such consistent and significant increases in serious health outcomes, even after balancing for many other risk factors,” said Dr. Nnadi.
Troxel, a senior scientist at the RAND Corporation, warned of the variability in melatonin dosages and the potential risks for children who may accidentally overdose. She urged individuals to consult healthcare professionals before using melatonin and recommended alternative treatments such as cognitive behavioral therapy for insomnia.
Limited by its observational nature, the study acknowledges that other factors like insomnia severity and mental health could influence the results. As researchers call for more in-depth studies to prove a direct cause-and-effect relationship, consumers are advised to exercise caution and consult healthcare experts before considering long-term melatonin use.