Dr. Daniel Amen, a renowned psychiatrist and founder of Amen Clinics in California, has suggested that saffron, a spice used extensively in Middle Eastern cuisine, may serve as a natural alternative to conventional antidepressants. During an interview with Fox News Digital, he discussed how the spice has shown comparable effectiveness to antidepressants in clinical studies, potentially offering a safer and more holistic approach to treating depression. He also highlighted saffron’s ability to improve sexual function, a benefit that is often negated by SSRIs, making it a potentially valuable option for patients concerned about its impact on their personal lives.
Research has indicated that saffron may also improve memory and focus. A 2025 study published in Reviews in Clinical Medicine found that regular use of saffron can significantly reduce symptoms of premenstrual syndrome (PMS), providing relief for women experiencing these issues. In another meta-analysis conducted in May 2025, saffron was found to have a moderate to large antidepressant effect, surpassing many other nutraceuticals in trials involving over 17,000 patients. This suggests that saffron could be a viable option for managing depression symptoms, particularly for those seeking alternatives to traditional pharmaceutical treatments.
However, experts warn that while saffron shows promise as a supplement, its long-term effects and safety remains under investigation. Researchers have cautioned that high doses or prolonged use may lead to side effects such as anxiety, appetite changes, upset stomach, or insomnia. As a result, individuals considering saffron as a treatment should consult with a healthcare provider to ensure it is both safe and appropriate for their specific needs. Amen also recommended combining saffron with other supplements like zinc and curcumin to enhance its antidepressant effects, providing a potential pathway for improved mental health outcomes.