Research has unveiled that saffron, a vibrant red spice often used in global cuisines, may possess the potential to serve as an effective natural antidepressant, with findings suggesting it might be as effective as traditional antidepressants for alleviating symptoms of depression. These discoveries were highlighted by Dr. Daniel Amen, a prominent psychiatrist and founder of Amen Clinics in California, who shared his insights on the topic during an exclusive interview with Fox News Digital.
The spice, which is a staple in various food preparations such as paella and herbal teas, has shown remarkable potential in enhancing mood and mitigating symptoms associated with depression, in addition to offering a range of other health benefits. Dr. Amen, who is of Lebanese descent, shared personal anecdotes highlighting the cultural significance of saffron, especially within Middle Eastern communities, where it is often used to elevate mood and is even humorously associated with happiness in Iranian folklore.
The study’s findings indicated that a daily dose of approximately 30 milligrams of saffron was found to be equally effective as prescription antidepressants in randomized clinical trials, according to the research. This is particularly noteworthy because many common antidepressants, such as selective serotonin reuptake inhibitors (SSRIs), while effective in improving mood, can inadvertently reduce sexual function, leading to concerns among patients and physicians alike. Saffron, however, appears to offer an alternative that may not share this drawback, aligning more closely with the goal of improving both mental health and sexual well-being.
In addition to its potential benefits for depression and sexual health, saffron has been linked to improved cognitive functions, including enhanced memory and focus. This makes it a versatile supplement that could appeal to a broad audience, especially in the context of an increasingly health-conscious society. Moreover, recent studies have suggested that saffron may play a role in alleviating symptoms related to premenstrual syndrome (PMS), offering yet another potential benefit to its users.
The research, published in the Reviews in Clinical Medicine 2025, has further corroborated these findings, highlighting the effectiveness of saffron in reducing PMS symptom severity. Another study published in the Cambridge University Press in May 2025 has shown that saffron could be beneficial in managing symptoms of depression, with a meta-analysis that reviewed 192 trials and over 17,000 participants, identifying saffron as the most effective among various nutraceuticals for depression treatment.
While saffron is now available in capsule, tablet, and powdered extract forms, the recommended dosage is typically around 30 milligrams per day. However, the long-term use of saffron is still under investigation, and experts warn that taking large doses for extended periods could pose risks, including anxiety, indigestion, sleep disturbances, and headaches. Therefore, it is crucial for individuals considering saffron supplementation to consult with a healthcare provider before incorporating it into their routine.
In conclusion, while the research on saffron’s potential benefits for mental health and sexual well-being is promising, more long-term studies are needed to fully understand its impact and ensure its safety. As such, individuals interested in using saffron as a supplement should seek professional guidance to make an informed decision about its use.