Week 12 of the 2025 NFL season is shaping up to be a pivotal moment for MVP candidates as premier quarterbacks and running backs take center stage in high-stakes matchups. The Los Angeles Rams’ Matthew Stafford will clash with Tampa Bay Buccaneers’ Baker Mayfield in a battle that could determine the MVP race. Meanwhile, the Indianapolis Colts, who have been making waves this season, face the powerhouse Kansas City Chiefs in a crucial showdown. Jonathan Taylor’s impressive performance has also placed him in the conversation for the award, with an average of 113 yards per game. The Eagles and Cowboys’ game is another major matchup, with the Eagles’ offensive struggles under scrutiny against Dak Prescott’s stellar season. Shedeur Sanders’ debut as quarterback for the Cleveland Browns will add another layer of intrigue, as he’ll face the formidable Las Vegas Raiders’ Maxx Crosby. These games could have significant implications for the playoff picture and the MVP race in the coming weeks.