Doctors are finding that GLP-1 medications, such as Ozempic, may show promise in treating rheumatoid arthritis (RA) alongside other inflammatory conditions. These drugs, which mimic a natural hormone called glucagon-like peptide-1, are traditionally used for diabetes control and weight loss. However, recent evidence suggests they might also help alleviate painful arthritis symptoms.
RA is a chronic autoimmune disease where the immune system attacks its own tissues, leading to inflammation, pain, and joint stiffness. Studies have linked being overweight or obese to a higher risk of developing RA. A 2020 study published in the journal Nature found that a higher body mass index (BMI) and waist circumference were associated with a greater prevalence of the condition.
Dr. Sue Decotiis, a medical weight-loss doctor in New York City, has seen patients experience significant relief from inflammatory arthritis after taking GLP-1s. She reported that many patients were able to stop their arthritis medications. Decotiis explained that fat cells produce substances like cytokines and adipokines that can increase inflammation and affect immune function.
While the exact mechanism of the anti-arthritis effect of GLP-1s remains to be fully understood, Decotiis emphasized that weight loss is a potential factor. She also noted other positive effects associated with these medications, including reduced alcohol intake and less reliance on anti-anxiety medications. The drugs have also been linked to a reduced risk of migraines, Alzheimer’s disease, and even some cancers.
Decotiis advised that anyone considering using GLP-1s should be under the supervision of a physician knowledgeable in their usage. She warned that individuals not overweight should be closely monitored, and she cautioned against accessing these drugs from online platforms without in-person physician care.